New study shows how IDO2 index could help bring attention to changes in patient risk sooner.  New data in Adult patients.

In intensive care settings, most serious deterioration develops gradually rather than suddenly, with abnormal vital signs detectable hours before significant events. This means that clinicians must monitor subtle physiologic changes to support timely assessment and decision-making.^1,2

However, continuous physiologic and laboratory monitoring generates vast amounts of data, and clinicians must constantly decide which signals warrant immediate review.

Early warning scores have been introduced to help identify early clinical deterioration but many established scoring systems have been found to have methodological weaknesses. ³

New data from a study of CTEPH patients by UTSW shows that Inadequate delivery of oxygen (IDO2) as an adjunctive prioritization index that may help bring attention to changes in patient risk sooner. The IDO2 Index synthesises multiple physiologic and lab inputs into a single risk context intended to highlight patients who may warrant closer clinical review.⁴

CTEPH is a life-threatening, progressive form of pulmonary hypertension caused by unresolved blood clots in the lungs and can lead to severe complications, including right heart failure. In the UTSW study, patients with higher inadequate delivery of oxygen (IDO2) levels within the first 24 hours postoperatively were associated with prolonged length of stay.

The IDO2 Index is a proprietary risk index available through the Etiometry Clinical Intelligence Platform. Etiometry’s AI uses Large Physiology Models (LPMs) to track deterioration and assess opportunities for interventions. With more than 200 million hours of patient data captured to date, the LPM combines data aggregation and visualization to present four FDA-cleared risk analytics algorithms for critical care. As well as IDO2, these indices also include Inadequate Ventilation of Carbon Dioxide (IVCO2), Hyperlactatemia (HLA) and Acidemia  (ACD) helping bring attention to changes in patient status that warrant the clinician’s review.

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References

1. https://link.springer.com/article/10.1007/s00134-002-1496-y
2.  https://www.sciencedirect.com/science/article/abs/pii/S030095720800052X
3.  https://www.ncbi.nlm.nih.gov/books/NBK259029
4.  Hoover, E., et al. (2025). Abstract A-1358, Adult Cardiac, New Technology/Miscellaneous. UTSW, Dallas, TX, United States.

Please note: Indices have specific indicated populations; see labeling